Laxocon^®

Laxocon is a preparation of Sodium Picosulfate. Sodium Picosulfate is a triarylmethane group derivative stimulant laxative. After administration it is activated by the colonic bacteria and acts locally in the colon. The active form then stimulates the nerve endings of the intestinal wall and results in colonic peristalsis with promotion of accumulation of water and electrolytes in the colonic lumen. This results in stimulation of defecation, reduction of transit time and softening of the stool. Stimulation of the rectum causes increased motility and a feeling of rectal fullness.

No Data

Laxocon is indicated in the following conditions:
• Constipation
• Relief from prolonged & recurrent constipation
• Bowel clearance before surgery, childbirth or radiological investigations

Route of administration: Laxocon® should be taken in oral route with adequate fluid. The maintenance of an adequate fluid intake during treatment is essential, especially for younger patients and the elderly who are more susceptible to the effects of dehydration.

The following dosages are recommended to be taken at night to produce evacuation the following morning. Laxocon® should not be taken every day for more than five days without investigating the cause of constipation. It is recommended to start with the lowest dose. The maximum recommended daily dose should not be exceeded.

Pregnancy: There are no reports of undesirable or damaging effects during pregnancy or to the fetus attributable to the use of this product. Use of the drug should be avoided during the first trimester.

Lactation: Caution is required during lactation as small amounts of this medicine may pass into breast milk.

Use in children and adolescents
Use in children and adolescents is given in dose and administration.

Prolonged excessive use of sodium picosulfate may lead to fluid and electrolyte imbalance and hypokalemia. Care should be taken in patients with recent gastrointestinal surgery and in patients with renal impairment, heart disease or inflammatory bowel disease. It should be used with caution in patients on drugs that might affect water and electrolyte balance e.g., diuretics, corticosteroids, lithium. Sodium picosulfate may modify the absorption of regularly prescribed oral medication and should be used with caution.

The most common side effects are dizziness, syncope, vasovagal response, abdominal discomfort, abdominal pain, abdominal cramps, diarrhea, nausea and vomiting.

It is contraindicated in patients with history of known hypersensitivity to sodium picosulfate or any other components of this product. It is also contraindicated in patients with gastrointestinal obstruction, ulceration or perforation, acute abdominal surgical conditions such as appendicitis, acute inflammatory bowel diseases and severe abdominal pain associated with nausea and vomiting, severe dehydration, undiagnosed rectal bleeding and acute hepatic failure.

Drug interaction with medication: The concomitant use of sodium picosulfate with diuretics or adrenocorticosteroids may increase the risk of electrolyte imbalance if excessive doses are taken. Concurrent administration of antibiotics may reduce the laxative action of this drug.

Drug interaction with food and others: Not applicable.

Chronic overdosage may cause chronic diarrhea, abdominal pain, hypokalemia, secondary hyperaldosteronism and renal calculi. Renal tubular damage, metabolic alkalosis and muscle weakness secondary to hypokalemia can also occur.

No Data

No Data

Laxocon tablet: Each tablet contains Sodium Picosulfate BP 10 mg.
Laxocon oral solution: Each 5 ml solution contains Sodium Picosulfate BP 5 mg.

Storage
Store below 30⁰C in a dry place, protected from light. Keep away from the reach of children.

Packing
Laxocon tablet: Carton of 30 tablets in blister pack.
Laxocon oral solution: Carton of 50 ml & 100 ml bottle.