Anaflex^®

Anaflex is a preparation of Naproxen which is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic properties. Naproxen is a propionic acid derivative related to the acrylic acid class of drugs. It works by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever and inflammation.

No Data

Anaflex is indicated for the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile rheumatoid arthritis, acute gout and acute musculoskeletal disorder (such as sprains and strains, direct trauma, lumbosacral pain, cervical spondylitis, tenosynovitis and fibrositis), migraine, post-operative pain and dysmenorrhea.

Adults
For rheumatoid arthritis, osteoarthritis, ankylosing spondylitis: The usual dose of Anaflex is 500 mg to 1 g per day taken in two divided doses at 12 hour intervals or as a single administration of Anaflex 500 mg or Anaflex SR 500 mg once daily (morning or evening) after meals.
For acute gout: The initial dose of Anaflex is 750 mg, and then 250 mg every eight hours until the attack subsides.
For analgesia and acute musculoskeletal disorders: The initial dose of Anaflex is 500 mg and then 250 mg at 6-8 hour intervals as needed with a maximum 1250 mg daily.
For dysmenorrhea: The usual dose of Anaflex is 500 mg should be given initially, followed by 250 mg at 6-8 hour intervals for up to 5 days.
For migraine: The usual dose of Anaflex is 500 mg should be given initially, then 500 mg at least 30 minutes after the initial dose.

Children over 5 years
In juvenile rheumatoid arthritis (children over 5 years): The usual dosage of Anaflex is 10 mg/kg/day taken in two doses at 12 hour intervals is recommended.
Anaflex Gel is to be applied 2-6 times a day as required and is not recommended for use in children.

The safety of naproxen administration during pregnancy and for use in nursing mother has not been established. Therefore, the possible hazards should be weighed against the potential benefits.

Naproxen should be used with care in patients with a history of Gl disease, asthma or allergic disease, impaired renal and hepatic function. Naproxen decreases platelet aggregation and prolongs bleeding time.

The most common side effects of naproxen are nausea, vomiting, pain, occasionally bleeding, ulceration, skin rashes, urticaria, angio-oedema; eosinophilic pneumonitis, thrombocytopenia, granulocytopenia, including agranulocytosis, aplastic anaemia, tinnitus, hearing impairment, vertigo, mild peripheral oedema (patients with compromised cardiac function may be at a higher risk on naproxen), fatal hepatitis, nephropathy, haematuria, visual disturbances, vasculitis, aseptic meningitis and ulcerative stomatitis.

Naproxen is contraindicated in patients active peptic ulceration, hypersensitivity to naproxen or naproxen sodium formulations, aspirin or other NSAIDs.

Caution is required if any of the following is administered concurrently with naproxen: hydantoins, anticoagulants or highly protein bound sulphonamides, furesamide, propranolol or other beta blockers, lithium, probenecid and methotrexate.

Overdose with naproxen may be characterized by drowsiness, heartbum, indigestion, nausea and vomiting. No evidences of toxicity or late sequel have been reported 5-15 months after ingestion, for three to seven days, of doses up to 3 g/day.

No Data

Protect from light, store bellow 30°C and keep away from children.

Anaflex 250 mg Tablet: Each enteric coated tablet contains Naproxen BP 250 mg.
Anaflex 500 mg Tablet: Each enteric coated tablet contains Naproxen BP 500 mg.
Anaflex SR 500 mg Tablet: Each tablet contains Naproxen BP 500 mg.
Anaflex Suspension: Each 5 ml contains Naproxen BP 125 mg.
Anaflex Gel: Each gram gel contains Naproxen BP 100 mg (Naproxen BP 10% w/w).

Storage
Store in a cool (below 300C) and dry place protected from light. Keep away from the reach of children.

Packing
Anaflex 250 mg Tablet: Carton of 50 tablets in blister pack.
Anaflex 500 mg Tablet: Carton of 30 tablets in blister pack.
Anaflex SR 500 mg Tablet: Carton of 20 tablets in blister pack.
Anaflex Suspension: Bottle of 50 ml.
Anaflex Gel: Tubes of 15 g and 30 g.