Povital^®

Povital is a combination of Vitamin B1 (Thiamine), B6 (Pyridoxine) & B12 (Cyanocobalamin). These vitamins play essential role as co-enzyme for the metabolism of nervous system. Thus this combination normalizes the nerve cell metabolism. Povital® supports the regeneration of nerve fibers and myelin sheath by activation of the metabolism and the natural repair mechanism. The combination of these three vitamins shows better efficacy than that of the individual components. In addition, Vitamin B1, Vitamin B6 & Vitamin B12 promote body's own repair mechanism and work in pain management.

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Povital is indicated for the prevention and treatment of deficiency of vitamin B1, B6 and B12. It is also indicated in the treatment of diabetic, alcoholic or toxic neuropathies, neuritis, facial neuralgia, peripheral neuralgia, intercostal neuralgia, spinal pain, lumbago, myalgia, sciatica and facial paresis.

Route of administration: Povital should be taken in oral route or administered intramuscularly. The recommended dose is 1 to 3 Povital® tablets daily or as recommendation of physician. The duration of treatment is stated by the physician. Povital injection may be administered intramuscularly (deep intragluteal) as a dose of 1 ampoule daily in severe cases until the acute symptoms subside. For milder cases and follow-up therapy two or three ampoules per week.

Pregnancy: Safety and effectiveness for pregnant women have been established and may be used in pregnancy.

Lactation: It is not known whether thiamine (Vitamin B1) is excreted in breast milk or not, but may be taken cautiously during lactation. Vitamin B6 & Vitamin B12 have no adverse effect during lactation.

Use in children and adolescents

Safety and effectiveness of this combination have not been established in children and adolescents below 18 years of age.

Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord. Cyanocobalamin is not a suitable form of Vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin. Concomitant use with pyridoxine and levodopa should be avoided.

There are no report of severe adverse reactions following the administration of this product.

It is contraindicated in patients with malignant tumors or suspected malignant tumors. It is also contraindicated in patients with hypersensitivity to thiamine, cobalt or any other components of this product.

Drug interaction with medication: Concomitant use with neomycin, chloramphenicol, aminosalicylic acid & histamine (H2) receptor antagonist may reduce vitamin B12 absorption.
Drug interaction with food and others: Black tea and beverages containing sulphite.

In case of overdose, symptomatic treatment and general supportive measures should be initiated.

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Povital Tablet: Each coated tablet contains Thiamine Nitrate (B1) BP 100 mg, Pyridoxine Hydrochloride (B6) BP 200 mg and Cyanocobalamin (B12) BP 200 mcg.
Povital Injection: Each 3 ml ampoule contains Thiamine Hydrochloride (B1) BP 100 mg, Pyridoxine Hydrochloride (B6) BP 100 mg and Cyanocobalamin (B12) BP 1 mg.

Storage
Store below 25° C in a dry place, protected from light. Keep away from the reach of children.

Packing
Povital Tablet: Container of 30 tablets & 7 tablets (for physician's sample only).
Povital Injection: Carton of 10 ampoules.